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KMID : 0665420200350020224
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Korean Journal of Food Culture
2020 Volume.35 No. 2 p.224 ~ p.232
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Fatty Acid Concentration of Serum Phospholipids in Normal and Glaucoma Patients
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Chung Hae-Yun
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Abstract
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Glaucoma is one of the leading causes of blindness worldwide and is characterized by degeneration of the optic nerve.
Elevated intraocular pressure (IOP) is the major contributing factor to optic nerve damage. However, some patients developglaucoma even with normal IOP. Other factors, including age, race, myopia, and nutrition, can affect glaucoma risk. Dietaryfat intake and serum fatty acid composition are closely related with the fatty acid profile of the retina and thus can modulateglaucoma risk. In this study, we collected serum samples from 34 glaucoma patients (26 primary open angle glaucoma(POAG) and 8 normal tension glaucoma (NTG)) and 45 healthy controls and analyzed their serum phospholipid fatty acidconcentrations. The results show that the ratio of oleic acid to stearic acid (OA/SA), which is an indicator of stearoyl-CoAdesaturase activity, was higher in POAG patients when compared to normal controls. The ratio of eicosapentaenoic acid toarachidonic acid (EPA/AA), which is an indirect marker of eicosanoid biosynthesis, was also higher in glaucoma patients(p=0.048). These results imply that dietary fatty acid intake and serum fatty acid profile can influence glaucoma risk.
Additional study is necessary to identify the relationship between fatty acids and glaucoma.
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KEYWORD
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Glaucoma, serum phospholipid, fatty acids
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